Adrien Brody and Sarah Polley are attractive and vivid genetic scientists. They're employed by NERD, a company that rides their work to the cusp of the next big bio-tech revolution. In between being quirky and listening to good music, they hit on a bio-engineering breakthrough. But why create a pig that produces human insulin? That's boring. How about a cat-sized fleshy slug that makes proteins that might cure everything! Sounds like a solid way to mass-produce an Alzheimer's cure, right?
Damn close to an "Alien" poster, huh?
Wrong. Remember that these scientists have only just attained their amazing goal of making two monstrosities and getting them to wink at each other ("Fred" and "Ginger"). For some reason (the plot, apparently), they have no interest in studying their creation fully, or even very much at all. The pair tell their boss they immediately want to start splicing (we have title!) human DNA into a third slug-thing. I only took a few science courses in college, but this sounds like an improbable (and dangerous) leap ahead.
How bad was "Splice?" I'll give, right now, five signs of how bad it was - all of these are firsts for me here... (1) Since they took time and effort to make a professionally-crafted motion picture, I'll take the time and effort to explain how they failed gloriously, but deeply. (2) I'm breaking my own trend and will spoil the hell out of the film after the next 14 paragraphs, but I'll post a warning before I start. (3) I will not edit overuse of words like "stupid" and "dumb" and "stupidity," unless I remove whole sentences or clauses. (4) I'll only bother to put the titles for "Splice," "The Bride of Frankenstein" and "Cube" in quotation marks. Just this once, correct punctuation - on something I must write well - isn't worth the extra effort.
Finally, (5) I'll first provide an synopsis of my in-theater thoughts, hoping that you read the rest of the review anyway. Here it is: