Most bittersweet last role?Hands down, it's Raúl Juliá in 1994's Street Fighter. On the one hand, you have a great performance from an amazing actor. On the other hand, it's in a laughably-entertaining movie based on a two-person fighting game with Jean-Claude Van Damme as the lead.
Raúl finally succumbed to the cancer that was taxing his body while filming - and he died before the film was even released. For an exceptional actor like Mr. Juliá, a class-act with such a fine career, this was an unfortunate note to end on.